Microsatellite instability in human prostate cancer

Microsatellite instability in colorectal cancer

BACKGROUND Colorectal cancer (CRC) is the third most common cancer in the world. In 75% CRC develops sporadically, in 25% hereditary or as a consequence of inflammatory bowel disease. CRC carcinogenesis develops over many years. The cause of CRC in 85% is chromosomal instability (CIN) and in 15% microsatellite instability (MSI-H), where hereditary nonpolyposis colorectal cancer (HNPCC) represen...

Microsatellite instability in colitis associated colorectal cancer.

Microsatellite instability is uncommon in breast cancer.

In some tumors, defects in mismatch repair enzymes lead to errors in the replication of simple nucleotide repeat segments. This condition is commonly known as microsatellite instability (MSI) because of the frequent mutations of microsatellite sequences. Although the MSI phenotype is well recognized in some colon, gastric, pancreatic, and endometrial cancers, reports of MSI in breast cancer are...

Microsatellite instability in colitis associated colorectal cancer

Microsatellite instability in colitis associated colorectal cancer As molecular pathways of colon carcinogenesis continue to be defined for high risk hereditary colon cancer syndromes and for average risk sporadic colon cancers, it seems that colon carcinogenesis in the setting of chronic idiopathic inflammatory bowel disease (IBD) may be unique. 1 Although to some extent this notion seems intu...

microsatellite instability in young women with endometrioid type endometrial cancer

background: this study was designed to determine the frequency of microsatellite instability (msi) in young iranian pa­tients with endometrial carcinoma and to evaluate its association with histopathologic and clinical features of disease. methods : microsatellite status was analyzed in 23 patients with endometrioid type endometrial cancer who were less than 55 years. clinicopathologic characte...